Go to menu

Current Research Trials

Sydney Retina Clinic and Day Surgery is proud to be associated with a research department named the Sydney Institute of Vision Science. All members of the research team have a strong background in both clinical and laboratory research and are dedicated to the development of new treatment for retinal disease.

Sponsored Trials

Derby

A Phase 3, Multicenter, Randomized, Double-Masked, Sham-Controlled Study to Compare the Efficacy and Safety of Intravitreal APL-2 Therapy with Sham Injections in Patients with Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (AMD).

EC-FCA-001 Study

Study of safety and tolerability of intravitreal Fludrocortisone Acetate (FCA) in patients with Geographic Atrophy (GA).

Exonate 

A Randomised, Double-Masked Vehicle-Controlled, Multiple Dose, Dose Escalation Study To Evaluate The Safety And Tolerability Of Exn407 In Subjects With Centre Involved Diabetic Macular Oedema Secondary To Diabetes Mellitus.

IONIS

A Phase 2, Randomized, Placebo-Controlled, Double-Masked Study to Assess Safety and Efficacy of Multiple Doses of IONIS-FB-LRX, an Antisense Inhibitor of Complement Factor B, in Patients with Geographic Atrophy Secondary to Age-Related Macular Degeneration (AMD)

ISEE2008

A Phase 3 Multicenter, Randomized, Double-Masked, Sham controlled Clinical Trial To Assess The Safety And Efficacy Of Intravitreal Administration Of Zimura™ (Complement C5 Inhibitor) In Patients With Geographic Atrophy Secondary To Dry Age-Related Macular Degeneration

Kestrel Study

A two-year, three arm, randomized, Double-Masked, Multicenter, Phase 3 study assessing the efficacy and safety of Brolucizumab versus Aflibercept in adult patients with visual impairment due to Diabetic Macular Edema (DME).

Lucerne

A Phase 3, Multicenter, Randomized, Double-Masked, Active Comparator-Controlled Study to Evaluate the Efficacy and Safety of Faricimab in Patients with Neovascular Age-Related Macular Degeneration.

OTX-TKI Study

The OTX-TKI study is a phase 1 open-label, dose escalation study of OTX-TKI (axitinib implant) for intravitreal use in subjects with neovascular Age-related macular degeneration (AMD).

Panda Study

A multicentre, double-masked, randomized, dose-ranging trial to evaluate the efficacy and safety of Conbercept intravitreal injection in subjects with Neovascular Aged-related Macular Degeneration (AMD).

Pulsar 

Randomized, Double-Masked, Active-Controlled, Phase 3 Study of the Efficacy and Safety of High Dose Aflibercept in Patients With Neovascular Age-Related Macular Degeneration.

Ripple

Evaluation of Safety and Efficacy of the IBE-814 Intravitreal Implant in Patients with Diabetic Macular Oedema and Macular Oedema due to Retinal Vein Occlusion

SCD411-CP101

A Phase III Randomized, Double Double-Masked, Parallel Group, Multicenter Study to Compare the Efficacy, Safety, Tolerability, Pharmacokinetics Pharmacokinetics, and Immunogenicity between SCD411 and Eylea ® in Subjects with Neovascular Age -related Macular Degeneration.

 

Investigator Initiated Studies

DONOR EYE
Clinicopathological Correlation in Macular Degeneration.

EYLEA RVO
Intravitreal Aflibercept for the treatment of treatment resistant retinal vein occlusions.